6th Edition of Neurology World Conference 2026

Abstract

Abstract: The Autonomic Nervous System (ANS) maintains homeostatic balance of the body by controlling involuntary physiological functions such as body temperature. While the brain’s hypothalamus and brainstem are primary brain areas that control the ANS, its limbic system is involved in emotional reactions such as anxiety and excitement, which can impart an effect on autonomic responses such as heart rate and blood pressure. Meanwhile, Piezo ion channels enable interpretation of sensory information conveyed through the Somatic Nervous System (SNS) of the Peripheral Nervous System (PNS) to be communicated between neurons in the brain, and also bidirectionally between the brain and the PNS. Piezo channels allow electrical current to pass through them. In this way, ion channels enable neurons (nerve cells) to communicate with each other, so that the brain’s neural networks can properly function. TRP ion channels stimulate neuronal cellular responses, while Piezo channels open in response to mechanical stimuli, so an interrelationship exists between them. Haptic Vibrotactile Trigger Technology (VTT) prompts a sensory response by using electrical current-producing vibrations to stimulate the skin’s mechano-receptors and is communicated via the PNS to the brain. Figure 1 The homotrimeric structure of Piezo-2 Results Outcomes from recent research of VTT randomized clinical trials (RCTs) have demonstrated positive effects (e.g., the reduction of anxiety, stress, depression, improvement in sleep, pain relief, balance and stability),which can prompt an ANS response such as lowering heart rate and/or blood pressure. Conclusions The bi-directional sensory communication promoted by VTT utilization may be able to boost the functioning of the piezoelectric channels. Evolving VTT treatments may be beneficial in people with diminished functioning of their piezoelectric channels.