6th Edition of Neurology World Conference 2026
Speakers - NWC 2023
Leyla Yavuz Saricay
Leyla Yavuz Saricay
- Designation: Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School
- Country: USA
- Title: Painful Neurotrophic Keratopathy
Abstract
Neurotrophic keratopathy (NK) is a degenerative corneal disease that is the result of impaired corneal innervation by the ophthalmic branch of the trigeminal nerve. Though NK is associated with decreased corneal mechanosensation, recent studies indicate that spontaneous pain can also occur in such patients. This presentation will review the state of the field regarding the relationship between symptoms of pain and the clinical ophthalmological measures in patients with NK, including an emphasis on in vivo corneal microscopy findings. NK is associated with decreased measures of corneal nerve density but also can demonstrate clinically significant pain along with increased dendritiform cell density, a marker of localized peripheral inflammation. Chronic ocular pain may develop with NK, with nerve damage and inflammation playing roles as contributing factors. Increased ocular pain with decreased corneal nerve fibers is suggestive of a sensitization and/or dysregulation of central nervous system circuits related to nociceptive processing.
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