6th Edition of Neurology World Conference 2026

Abstract

Amyotrophic Lateral Sclerosis, ALS, is a progressive neurodegenerative disease usually of unclear cause(s) and no documented, highly-effective treatments. Multi-factorial causes have been postulated in the literature, yet medications only target single metabolic pathways. When ALS patients are educated on the possible contributing factors and exposure risks to ALS and are empowered to apply individualized, non-toxic, therapeutic interventions, the functional outcome measures are better than predicted in the peer-reviewed literature.

ALS is reportedly irreversible, leading to death within 3-5 years of diagnosis. However, there are 46 published cases and at least 65 confirmed reversal cases of ALS by Duke University. Reversals have been defined as a dramatic and persistent recovery of lost motor function, at least 4 points of improvement on the ALS Functional Rating Scale-Revised (ALSFRS-R) for at least 12 months, as well as meeting certain other criteria. Reversals have been associated with a combination of potential factors such as rigorous dietary changes, certain well-chosen supplements, stress-reduction and other consistent changes in lifestyle, reducing body burden of environmental toxins and other mostly self-administered interventions. This research aimed to develop an online education platform on the largely self-administered approaches, together with a patient registry to help people with ALS track their concurrent interventions and disease progression, and to learn from others following a similar path.  

The Healing ALS registry provides a framework for ALS patients to enter and track their multiple conventional and alternative interventions, and their overall effectiveness using self-reported outcomes.  Monthly data is collected for ALSFRS-R, as well as detailed physical and environmental factors, laboratory results, dietary intake, medications, supplements, and emotional/psychological changes. All of this allows the ALS patient to observe which combinations of interventions are producing beneficial effects and which are producing detrimental effects.

Through observation, it was discovered that root-cause identification, coupled with non-invasive, root-cause-targeted interventions, slowed ALS progression relative to standard of care. In addition to reporting the number of patients who improved, remained stable, or declined in function, this presentation examines associations between outcomes and interventions.

Because it is difficult to be certain which interventions were most beneficial in this pilot study of only 45 patients, we have obtained approval from an Institutional Review Board to conduct a new 1000 patient observational study, the HAROS study, which we have registered on www.clinicaltrials.gov, and we have started enrolling ALS patients into this study in early 2026.